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ISA27 restores p53 function in GBM cells.

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posted on 2013-08-19, 03:55 authored by Barbara Costa, Sara Bendinelli, Pamela Gabelloni, Eleonora Da Pozzo, Simona Daniele, Fabrizio Scatena, Renato Vanacore, Pietro Campiglia, Alessia Bertamino, Isabel Gomez-Monterrey, Daniela Sorriento, Carmine Del Giudice, Guido Iaccarino, Ettore Novellino, Claudia Martini

4A) ISA27 induces p53 target gene expression: Real-time PCR analyses showed a statistically significant increase in MDM2 and p21 mRNA levels following short-term ISA27 treatment in U87MG cells. 4B) ISA27 induces cell cycle arrest: Cell cycle analysis (24 h) revealed a statistically significant increase in the G1 fraction and a nearly complete depletion of the S-phase population in short-term-treated U87MG cells.

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