ISA27 restores p53 function in GBM cells.

<p><i>4A</i>) <i>ISA27 induces p53 target gene expression</i>: Real-time PCR analyses showed a statistically significant increase in MDM2 and p21 mRNA levels following short-term ISA27 treatment in U87MG cells. <i>4B) ISA27 induces cell cycle arrest</i>: Cell cycle analysis (24 h) revealed a statistically significant increase in the G1 fraction and a nearly complete depletion of the S-phase population in short-term-treated U87MG cells.</p>