IFNγ signaling in CD11c+ DCs, but not myeloid cells, is required for the development of Th1-Treg cells.
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posted on 2015-02-06, 06:30 authored by Hyang-Mi Lee, Anne Fleige, Ruth Forman, Sunglim Cho, Aly Azeem Khan, Ling-Li Lin, Duc T. Nguyen, Aisling O'Hara-Hall, Zhinan Yin, Christopher A. Hunter, Werner Muller, Li-Fan LuFACS analysis and frequencies of T-bet+ or CXCR3+ cells in Foxp3+CD4+ Treg cells in (A) Spl and (B) LP isolated from CD11ccreIFNγR2fl/fl, LyzcreIFNγR2fl/fl and WT control mice. FACS data are representative of four independent experiments (*p<0.05; **p<0.01).
