Hsp90 kinase genetic interaction network.

Of the 226 interactions, 34 are with kinases. Kinases are color-coded depending on their degree of connectivity, ranging from grey for one connection to orange for five connections. Kinases and test conditions (black squares) are connected with each other via edges. While the caspofungin screen shared only one of its kinase interactors (CKB2) with another screen, every other screen shared half or more of its interactors with another screen. For six kinases (diamonds), protein levels were measured upon Hsp90 depletion.