Hepatic gene expression levels and circulating IL-6 levels.
2013-02-20T13:56:29Z (GMT) by
<p>mRNA expression of TNFα (A), and IL-6 (B) in liver from bone marrow transplanted LDLr KO mice. Gene expression analysis was performed by RT-PCR. Values are relative to the average expression of housekeeping genes and expressed as fold induction compared to WT transplanted controls. Values are mean ± SEM, n≥3 mice per group as compared to WT. Increased circulating IL-6 levels in LDLr KO mice transplanted with ABCA1/apoE double KO bone marrow (C). Serum from the transplanted LDLr KO mice was collected at 17 weeks after transplantation including 9 weeks of WTD feeding. Values are mean ± SEM, n≥8 mice per group. *p<0.05, **p<0.01. ***p<0.001 as compared to WT transplanted controls. <sup>#</sup>p<0.05 as compared to ABCA1 KO transplanted animals.</p>