Haemolysis and acanthocytosis in <i>ms/−</i> mice.

<p>(<b>A</b>) Serum of control (<i>+/−</i>) and mutant (<i>ms/−</i>) males obtained by centrifugation. (<b>B</b>) Peripheral blood smears of <i>ms/−</i> mice showing increased numbers of acanthocytes. High magnification images of a normal and an abnormally-shaped erythrocyte are shown (insets). Six animals from both the control and <i>ms/−</i> male groups were examined and one typical sample of each is shown. Bars correspond to 5 µm. (<b>C</b>) Plasma levels of haptoglobin (Hp) were assessed by western blotting as described in the Experimental section. The blot was reprobed with monoclonal anti-actin antibody as a loading control.</p>