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H2O2-induced vasoconstriction is mediated by COX-1.

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posted on 2014-08-05, 06:54 authored by Viktória Csató, Attila Pető, Ákos Koller, István Édes, Attila Tóth, Zoltán Papp

Arteriolar constrictions (control, as given in Fig. 1A, closed symbols) were prevented in the presence of the non-specific COX inhibitor indomethacin (10 µM, n = 5 arterioles from 4 different animals, preincubation for 30 min, id: 111±3 µm, open symbols; panel A). Panel B: The roles of COX isoforms in H2O2-evoked responses were studied by comparing vascular diameters in the absence of COX inhibitors (dotted line) with those in the presence of COX-1 inhibitor SC-560 (1 µM, n = 5 arterioles from 3 different animals, id: 113±14 µm; open squares) or with COX-2 inhibitor celecoxib (3 µM, n = 4 arterioles from 4 different animals, id: 146±13 µm; open triangles). Asterisks denote significant differences from the control.

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