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Genomic context of novel associations.

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posted on 21.04.2011 by Guillaume Paré, Paul M. Ridker, Lynda Rose, Maja Barbalic, Josée Dupuis, Abbas Dehghan, Joshua C. Bis, Emelia J. Benjamin, Dov Shiffman, Alexander N. Parker, Daniel I. Chasman

Genomic context for each of the four novel loci with significant association with sICAM-1 concentration. (A) RELA locus (11q13.1); (B) SH2B3 locus (12q24.12); (C) PNPLA3 locus (22q13.31); and (D) NFKBIB locus (19q13.2). Upper panel: Genes from RefSeq release 25. Only one isoform is shown when multiple splicing variants are known. Lower Panel: SNPs are shown according to their physical location and –log10 P-values for association with sICAM-1 (red dots). The red line represents the genome-wide significance threshold of 5×10−8. Also shown is the genetic distance in cM from the lowest P-value SNP (light grey line) along with the position of recombination hotspots (light grey vertical bars). Recombination rates and hotspots are based on HapMap data, as described by McVean et al. [43] and Winckler et al. [44].