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Genipin reduces UCP2 expression induced by high glucose in podocytes.

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posted on 2013-02-20, 02:18 authored by Wenjing Qiu, Yang Zhou, Lei Jiang, Li Fang, Lu Chen, Weifang Su, Ruoyun Tan, Chen-yu Zhang, Xiao Han, Junwei Yang

(a) Western blot analysis shows the results of UCP2 in podocytes incubated with D-Glucose for different time periods as indicated. The membrane was reprobed with actin to confirm equal loading of each lane. (b) Graphic presentation of relative UCP2 abundance normalized to actin. *P<0.05 vs. control. n = 3. (c) Western blot analysis shows that pre-incubation with genipin inhibited glucose-induced UCP2 expression. The membrane was reprobed with actin to confirm equal loading of each lane. (d) Graphic presentation of relative UCP2 abundance normalized to actin. *P<0.05 vs. control. #P<0.05 vs. glucose incubated cells without genipin pre-treatment. n = 3.

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