Figure_6.tif (371.7 kB)
Genetic ablation of β4 results in larger BK channel currents in CA3 pyramidal neurons.
figure
posted on 2012-03-16, 01:58 authored by Sonal Shruti, Joanna Urban-Ciecko, James A. Fitzpatrick, Robert Brenner, Marcel P. Bruchez, Alison L. Barth(A) Fluorescent image of a living slice from a β4−/− knock-out mouse showing GFP-signal in hippocampus. Scale bar: 500 µm. (B) Mean total potassium current from β4 heterozygote (β4+/−) and β4 knock-out (β4−/−) mice. (C) Example paxilline-sensitive BK channel current from representative CA3 neurons in β4+/− and β4−/− mice. (D) Mean amplitude of paxilline-sensitive BK channel current in β4+/− and β4−/− mice.