gnpl_a_1531859_sm6672.pdf (2.46 MB)
(±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear
journal contribution
posted on 2018-12-06, 06:33 authored by Fu-Ying Qin, Yong-Ming Yan, Zheng-Chao Tu, Yong-Xian Cheng(+)- and (−)-gancochlearols A (1) and B (2), two pairs of dimeric mertoterpenoid enantiomers were isolated from the fruiting bodies of Ganoderma cochlear. Their structures were identified by spectroscopic methods. Biological assessments show that the enantiomers of 1 and 2 are cytotoxic against three human cancer cell lines (A549, K562, Huh-7) and could inhibit COX-2 expression with IC50 values less than 10 μM.