GSA-Tumor analysis of <i>CCNB1</i> using the 1881-sample breast cancer data set.

<p>(A) Box plot of <i>CCNB1</i> gene expression for tumor samples stratified according to PAM50 subtypes <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0017911#pone.0017911-Parker1" target="_blank">[24]</a>. (B) Box plot of <i>CCNB1</i> gene expression for tumor samples stratified according to histological grade. (C) Association with outcome for <i>CCNB1</i> gene expression levels in subgroups of breast cancer using DMFS as endpoint and 10-year censoring. Samples in the 1881-sample set were stratified into three quantiles based on <i>CCNB1</i> expression, <i>CCNB1</i>_low (log2 expression −2.9 to −0.497), <i>CCNB1</i>_medium (−0.48 to 0.416), and <i>CCNB1</i>_high (0.42 to 2.8) followed by Kaplan-Meier survival analysis in 21 subgroups for 1379 cases with DMFS follow-up. Logrank P-values are shown as −log10(P-value). (D) Kaplan-Meier analysis, using DMFS as endpoint, for ER-positive tumors (n = 856) stratified into the three quantiles based on <i>CCNB1</i> gene expression level. (E) Corresponding multivariate analysis for ER-positive tumors (n = 554) using lymph node status and stratified histological grade (histological grade 1 and 2 vs. 3) as covariates and DMFS as endpoint with 10-year censoring.</p>

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