Functional complementation of yeast deletions by Brugia malayi (Bm) or Homo sapiens (Hs) orthologous genes.

Relative growth of yeast strains expressing the parasite or human target compared to the growth of yeast strains expressing the native gene. Blue bars indicate the full expression of the heterologous genes from the TetO2 promoter, and red and green bars indicate the growth of strains with a reduced expression of the essential enzyme.