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Flowchart and comparisons of prediction accuracy.

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posted on 2011-11-07, 01:30 authored by Ming-Huang Chen, Wu-Lung R. Yang, Kuan-Ting Lin, Chia-Hung Liu, Yu-Wen Liu, Kai-Wen Huang, Peter Mu-Hsin Chang, Jin-Mei Lai, Chun-Nan Hsu, Kun-Mao Chao, Cheng-Yan Kao, Chi-Ying F. Huang

(A) The CMap analysis flowchart. All eight sets from EHCO2 (Group 1), 100-member random sets, Frequent sets, and Clique sets (Group 2) were individually queried with CMap. Only drugs with a p-value of less than 0.05 and a negative enrichment score were retained. (B) Comparison of the accuracy of predicted drugs from each set. The top 10 drugs from each set were labeled according to their anti-cancer effects. (C) The comparison of the Frequency sets and the Clique sets. The average effectiveness of drugs was compared side by side.

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