Flow resistance in imaging and generated portions of the airway tree.

Analysis of contribution of the central and generated airways to total airflow resistance in the airway trees. Panels A and B show a kernel density plot of the fraction of total airflow resistance in the complete conducting models contributed by the algorithmically generated airways using Poiseuille resistance (A) and resistance at the high flow rate (1.67 L/s), colour indicates patient GINA classification (Green: Healthy, Blue: GINA 1–2, Red: GINA 3–5). A mean of 66% (Poiseuille resistance) to 44% (high flow rate) can be attributed to the generated airways. Similar plots for each of the individual groups are shown in Fig B in S1 File.