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Epileptiform discharges recorded by MEA.

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posted on 2014-03-21, 03:23 authored by Xin-Wei Gong, Jing-Bo Li, Qin-Chi Lu, Pei-Ji Liang, Pu-Ming Zhang

A: An example of hippocampal slice mounted on MEA. CA1, CA3a, CA3b and CA3c, fields of the hippocampus; DG, dentate gyrus; al, alveus; so, stratum oriens; pcl, pyramidal cell layer; sr, stratum radiatum; sl-m, stratum lacunosum moleculare; ml, molecular layer; gcl, granule cell layer; pl, polymorphic layer. B: Simultaneous extracellular recording of the hippocampal slice at about 30 min after the start of Mg2+-free ACSF perfusion. The channel number of each electrode is labeled at its top right corner. Several channels were closed (blank grids) because of a low signal-to-noise ratio. The two gray dashed curves illustrate the positions of pyramidal cell layer and granule cell layer. C: Epileptiform discharges displayed in different time scales. The epileptiform discharges were recorded by electrode #23, which is indicated by a black square in (A). D: Ensemble mean (black line) and standard deviation (dark gray shade) of 50 epileptiform discharges. Three blocks of light shades indicate the early, middle and late stages of epileptiform discharges.

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