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Enhance hippocampal CA1 LTP in Dyt1 heterozygous KO mice.

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posted on 2015-03-23, 04:28 authored by Fumiaki Yokoi, Huan-Xin Chen, Mai Tu Dang, Chad C. Cheetham, Susan L. Campbell, Steven N. Roper, J. David Sweatt, Yuqing Li

Compared to their control mice, there was a significantly enhanced LTP in Dyt1 heterozygous KO (+/Δ) mice. The dashed lines indicate the mean basal synaptic responses and time 0 min indicate the induction of LTP by theta burst stimulation. Inset shows representative traces 4 min before (black traces) and 2hr after LTP (red). Average results from control and the mutant slices were plotted (means ± errors). Open circles represent data from WT littermates. Filled circles represent data from the Dyt1 heterozygous KO mice.

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