Efficacy of benznidazole (Bz) and itraconazole (Itz) treatments for 20 days (monotherapy or combination) in murine model of acute Trypanosoma cruzi infection.

1 Swiss female weight 18 to 22g were inoculated with 5x103 trypomastigotes (Y strain), treatment was initiated at 4 days after inoculation followed by 20 days and it was administered per oral route.

2 Mean of doses (or days of treatment) required to induce the parasitemia supression.

3 Fresh blood examination (FBE) before and after cyclophosphamide immunosuppression and PCR assays performed at 1st and 6th month post-treatment.

Efficacy of benznidazole (Bz) and itraconazole (Itz) treatments for 20 days (monotherapy or combination) in murine model of acute Trypanosoma cruzi infection.