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Effects of replenishment of IL-13 in DSS-induced colitis.

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posted on 2013-08-28, 01:31 authored by Md. Sharif Shajib, Huaqing Wang, Janice J. Kim, Ivana Sunjic, Jean-Eric Ghia, Emmanuel Denou, Matthew Collins, Judah A. Denburg, Waliul I. Khan

IL-13−/− mice were treated with rmIL-13 (2 µg/day) injections or vehicle. rmIL-13 treatment started 3 days prior to 5 days of 5% DSS treatment. All groups received 5% DSS in the drinking water to induce colitis. (A) Number of 5-HT expressing EC cells per 10 glands and (B) colonic 5-HT content. (i) and (ii) Representative micrograph and arrows indicate 5-HT expressing EC cells. *Represents statistical significance where p<0.05.

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