Figure_2.tif (978.72 kB)
Effects of propofol and ketamine anesthesia on dendritic protrusions in the somatosensory cortex in vivo.
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posted on 2013-02-21, 04:37 authored by Mathias De Roo, Paul Klauser, Adrian Briner, Irina Nikonenko, Pablo Mendez, Alexandre Dayer, Jozsef Z. Kiss, Dominique Muller, Laszlo Vutskits(a) 3D volume rendering of confocal microscopy images of apical dendrites in control (left), propofol-treated (middle) and ketamine-treated (right) PND 15 mice. Scale bars: 1 µm. (b) Protrusion density of pyramidal neurons of the SCC of mice sacrificed at PND 15; 20 and 30 just after a 5 h-anesthesia with propofol (Propo) or ketamine (Keta) compared to control conditions (ctrl). (c) spine head width at PND 15 after 5 h-propofol (Propo) or Ketamine (Keta) anesthesia compared to control group. (b, c): n = 4 animals per group, 6945 spines; ***: P<0.001, **: P<0.01, *: P<0.05, two-way ANOVA with Bonferroni post tests.
