Effects of olmesartan on the left ventricular fibrosis and on connective tissue growth factor (CTGF) and collagen type 1 gene expression.
Panel A: Histology of the left ventricle stained with Masson’s trichrome in NTG, Gαq-TG, and Gαq-TG+olmesartan mice. Original magnification: 40×. Panel B: Comparison of the fibrosis fraction in the left ventricle in NTG, Gαq-TG, and Gαq-TG+olmesartan mice. Panels C and D: Quantitative analyses of CTGF (C) and collagen type 1 (D) gene expression by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in NTG, Gαq-TG, and Gαq-TG+olmesartan hearts. Data for CTGF and collagen type 1 were normalized to those for ARPP0. Data are the mean ± SE obtained from 6 mice for each group.