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Effects of olmesartan on the left ventricular fibrosis and on connective tissue growth factor (CTGF) and collagen type 1 gene expression.

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posted on 2014-08-29, 03:14 authored by Naoko Matsushita, Toshihide Kashihara, Hisashi Shimojo, Satoshi Suzuki, Tsutomu Nakada, Yasuchika Takeishi, Ulrike Mende, Eiichi Taira, Mitsuhiko Yamada, Atsushi Sanbe, Masamichi Hirose

Panel A: Histology of the left ventricle stained with Masson’s trichrome in NTG, Gαq-TG, and Gαq-TG+olmesartan mice. Original magnification: 40×. Panel B: Comparison of the fibrosis fraction in the left ventricle in NTG, Gαq-TG, and Gαq-TG+olmesartan mice. Panels C and D: Quantitative analyses of CTGF (C) and collagen type 1 (D) gene expression by real-time reverse transcriptase-polymerase chain reaction (RT-PCR) in NTG, Gαq-TG, and Gαq-TG+olmesartan hearts. Data for CTGF and collagen type 1 were normalized to those for ARPP0. Data are the mean ± SE obtained from 6 mice for each group.

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    arrhythmia32 weeksangiotensin II type 1G αq mouse modelHeart failuredecrease ACE expressionsmhcChronic olmesartan administrationgeneangiotensin II type 1 receptor activationtrpcGalpha q Causes Angiotensin II Type 1 Receptor ActivationctgfNTG mouse ventriclesTransgenic Mice BackgroundTransgenic miceanpbnpG αq exhibtProgressive Heart Failureconstitutivelyqt

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