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Effects of lack of IL-13 in DNBS-induced colitis.

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posted on 2013-08-28, 01:31 authored by Md. Sharif Shajib, Huaqing Wang, Janice J. Kim, Ivana Sunjic, Jean-Eric Ghia, Emmanuel Denou, Matthew Collins, Judah A. Denburg, Waliul I. Khan

WT and IL-13−/− mice were given DNBS (3 mg/100 µL) in 50% ethanol solution. All controls received 50% ethanol via intrarectal installation. Mice were sacrificed on day 3 following induction of DNBS colitis. (A) Macroscopic scores and (B) Histologic scores. (i) and (ii) Representative micrographs. From colonic tissue (C) IL-1β (D) IL-6 levels (E) MPO activity, and (F) 5-HT levels. *Represents statistical significance where p<0.05.

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