Effects of lack of IL-13 in DNBS-induced colitis.
WT and IL-13−/− mice were given DNBS (3 mg/100 µL) in 50% ethanol solution. All controls received 50% ethanol via intrarectal installation. Mice were sacrificed on day 3 following induction of DNBS colitis. (A) Macroscopic scores and (B) Histologic scores. (i) and (ii) Representative micrographs. From colonic tissue (C) IL-1β (D) IL-6 levels (E) MPO activity, and (F) 5-HT levels. *Represents statistical significance where p<0.05.