Effects of intracellular treatment with 5- or 40-nm AuNPs on seizure models.

(A, B) Prolonged SRF experiment. (A) The representative traces of repetitive firings elicited by long (10 sec) depolarizing current pulses. (B) PDS-like spikes, an epiletiform activity, were observed from a portion of AuNP-treated hippocampal CA1 neurons. (C) The representative traces of low Mg²⁺-induced bursts of spikes. Arrow head indicates a burst of spikes. (D) Intracellular 40-nm AuNPs increased the number of bursts. Average number of bursts per min were presented. *p<0.05, Student's t-test; N.S., no significance.