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Effects of intracellular treatment with 5- or 40-nm AuNPs on AP properties in hippocampal CA1 neurons.

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posted on 2014-03-13, 08:58 authored by Seungmoon Jung, Minji Bang, Byung Sun Kim, Sungmun Lee, Nicholas A. Kotov, Bongsoo Kim, Daejong Jeon

(A) AuNPs of both sizes significantly decreased the latency to the first AP. The 40-nm AuNPs significantly reduced the AP threshold (B) and AP duration (C). (D) AuNPs of both sizes significantly increased AHP. (E) AuNPs did not affect the AP amplitude. *p<0.05, **p<0.01, Student's t-test, No AuNPs vs. 40-nm AuNPs; #p<0.05, Student's t-test, No AuNPs vs. 5-nm AuNPs; N.S., no significance.

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