Effects of INMAP overexpression on the expression of genes related to proliferation and apoptosis.

(A). Western blot analysis of the three groups of cells (HeLa, Flag-HeLa, and Flag-INMAP) with anti-Bcl-2, anti-p53, anti-p21 and anti-PCNA antibodies. Data shown are representative of three independent experiments. (B). Band quantification was analysed with Image J software. (C). A schematic model illustrating the proposed mechanisms of INMAP-overexpression-induced DNA damage and apoptosis through p53-dependent pathways in transformed cells.