Effect of reversing remodeling of individual targets on CaT and AP characteristics in cAF.

<p>(A) chronic atrial fibrillation (cAF: all). (B–E) four restored cellular components (L-type Ca<sup>2+</sup> current, I<sub>CaL</sub>; inward rectified K<sup>+</sup> current, I<sub>K1</sub>; Na<sup>+</sup>/Ca<sup>2+</sup> exchanger current, I<sub>NCX</sub>; and increased cell volume, dilation), respectively. Columns from left to right: action potential (AP), Ca<sup>2+</sup> transient (CaT) averaged over cell volume, and spatiotemporal presentation of CaT (x =  distance from sarcolemma). Colour scale for right column: 0–1.5 µM corresponds to dark blue – dark red (similar to <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1003620#pcbi-1003620-g001" target="_blank">Figure 1</a> F&G). All results are obtained at BCL = 1000 ms.</p>