Fig_1.tif (564.15 kB)
Effect of crizotinib (A-C) or alectinib (D-F) on firing rate of retinal ganglion cells.
figure
posted on 2015-08-13, 03:05 authored by Toshiyuki Ishii, Shunichiro Iwasawa, Ryota Kurimoto, Akemi Maeda, Yuichi Takiguchi, Makoto KanedaThe timing of the drug application is indicated by the bar above the traces. The drug concentration was 1.0μM for both crizotinib and alectinib. The results for no change-type (A, D), increase-type (B, E), and decrease-type (C, F) cells are shown. The retina was repeatedly exposed to a set of light stimuli (1-s bright stimulation and 1-s dark stimulation at a frequency of 0.5 Hz). The ordinate shows the average firing rate for 10 cycles of stimuli (20 s).