EP2 and EP4 receptor expression is heightened in epidermis and papillomas from Tpl2<sup>−/−</sup> mice.

<p>Shaved wildtype and Tpl2<sup>−/−</sup> mice were treated with TPA (10 µg) for 0, 4, 8, 12, or 24 hours and analyzed for expression of EP2 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056212#pone-0056212-g004" target="_blank">Figure 4A</a>) or EP4 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056212#pone-0056212-g004" target="_blank">Figure 4C</a>). Additionally, papillomas from wildtype and Tpl2<sup>−/−</sup> mice were analyzed for expression of EP2 (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0056212#pone-0056212-g004" target="_blank">Figure 4B</a>). Magnification = 10X.</p>