EC<sub>50</sub> values (nM) of tGnRHs for intracellular calcium ion mobilization in HEK293-MSR cells expressing only Ci-GnRHR1 or co-expressing Ci-GnRHR1 and 4.

<p>The EC<sub>50</sub> values of tGnRH-6 are underlined to emphasize the dramatic increase in the potency on the cells co-transfected with Ci-GnRHR1 and 4.</p>