Dynamics of stable Type 1 CNV (S11 CNV).

<p>A) Total number of <b>stalk cells</b> vs. <b>time</b>. B) Total number of <b>stalk cells</b> confined in the <b>sub-RPE</b> space vs. <b>time</b>. C) Total number of <b>stalk cells</b> in contact with the <b>POS</b> (<b>stalk cells</b> in the <b>sub-retinal</b> space) vs. <b>time</b>. D) Total number of <b>RPE cells</b> vs. <b>time</b>. E) Total contact area between <b>RPE cells</b> and <b>BrM</b> vs. <b>time</b>. F) Total contact area between <b>POS cells</b> and <b>BrM</b> vs. <b>time</b>. The different colors represent the dynamics of 10 simulation replicas of the adhesion scenario (<i>RRl</i> = 3, <i>RRp</i> = 3, <i>RBl</i> = 2, <i>RBp</i> = 2, <i>ROl</i> = 3) (<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1002440#pcbi.1002440.s005" target="_blank">Table S5</a>, adhesion scenario ID: 38). (A, B) <b>CNV</b> initiates in 9 out of 10 simulation replicas. All develop <b>Early Type 1 CNV</b>. <b>CNV</b> remains confined in the <b>sub-RPE</b> space during one simulated <b>year</b> (<b>Stable Type 1 CNV</b>). A Fully developed <b>sub-RPE</b> capillary network contains about 45 <b>stalk cells</b> (∼3000 <b>cells</b>/mm<sup>2</sup>). In 5 simulation replicas a few <b>stalk cells</b> die during the simulated <b>year</b> due to lack of <b>RPE-derived VEGF-A</b>. (C) <b>Stalk cells</b> have minimal contact with the <b>POS</b>. (D, E) The <b>RPE</b> remains viable and its total contact area with <b>BrM</b> decreases as <b>stalk cells</b> proliferate. (F) The <b>POS</b> never contacts <b>BrM</b>, indicating that the <b>RPE</b> does not develop any holes.</p>