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Distribution of aberrant methylation of DBC1 and CDKN2B promoters in two independent AML series.

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posted on 2010-08-16, 01:36 authored by Sara Alvarez, Javier Suela, Ana Valencia, Agustín Fernández, Mark Wunderlich, Xabier Agirre, Felipe Prósper, José Ignacio Martín-Subero, Alba Maiques, Francesco Acquadro, Sandra Rodriguez Perales, María José Calasanz, Jose Roman-Gómez, Reiner Siebert, James C. Mulloy, José Cervera, Miguel Angel Sanz, Manel Esteller, Juan C. Cigudosa

MLL, mixed lineage leukemia; MSP, methylation-specific polymerase chain reaction; N, number of cases. (*)The frequencies of methylated DBC1 and CDKN2B in both sets of samples were compared in all categories using the Fisher exact test. There were no statistical differences in the frequencies, except for (**) p = 0.001 and (***) p = 0.28.

Other: Cases with no available cytogenetic data.

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