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Degrees of protein fold disruption in natural and simulated HIV-1 recombinants.

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posted on 2014-06-17, 03:06 authored by Michael Golden, Brejnev M. Muhire, Yves Semegni, Darren P. Martin
1

The p-value is the probability that mimic recombination breakpoints do not tend to avoid disrupting protein folding to a greater degree than S-recombinants.

2

Covarying contact model of coevolution. Amino acids within van der Waals contact in the 3D structure were considered to be potentially covarying. The p-value is determined from a comparison of observed numbers of coevolving residues that are segregated by recombination with numbers predicted under random recombination.

3

Mutual information model of coevolution. Amino acids in contact in the 3D structure with associated mutual information values >0.25 were considered to be potentially covarying. P-values were determined as in 2.

4

Not determined.

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