Degrees of protein fold disruption in natural and simulated HIV-1 recombinants.

1<p>The p-value is the probability that mimic recombination breakpoints do not tend to avoid disrupting protein folding to a greater degree than S-recombinants.</p>2<p>Covarying contact model of coevolution. Amino acids within van der Waals contact in the 3D structure were considered to be potentially covarying. The p-value is determined from a comparison of observed numbers of coevolving residues that are segregated by recombination with numbers predicted under random recombination.</p>3<p>Mutual information model of coevolution. Amino acids in contact in the 3D structure with associated mutual information values >0.25 were considered to be potentially covarying. P-values were determined as in <sup>2</sup>.</p>4<p>Not determined.</p>