DNMAML expression does not inhibit oncogenic K-ras mediated ADM <i>in vitro</i>.

<p>(<b>A</b>) Pancreatic explants from <i>Pdx1-Cre;LSL-Kras<sup>G12D</sup></i> mice at Day 2, infected with control adenovirus (Ad-empty) or Adenovirus expressing DNMAML (Ad-dnMAML/GFP). Representative brightfield images of ductal cysts shown. Scale bar, 100 µm. (<b>B</b>) <i>Pdx1-Cre;LSL-Kras<sup>G12D</sup></i> acinar explants expressing DNMAML-GFP form cytokeratin positive cysts. Explants were stained with antibodies against GFP (green) and pan-cytokeratin (red). Nuclei are counterstained with Hoechst (blue). Images are representative of 3 separate experiments. Scale bar, 20 µm. (<b>C</b>) DNMAML expression inhibits Notch signaling in <i>Pdx1-Cre;LSL-Kras<sup>G12D</sup></i> acinar explants. Explants were stained with antibodies against GFP (green) and Hes1 (red). Nuclei are counterstained with Hoechst (blue). Scale bar, 20 µm.</p>

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