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DMSO pre-treatment reduces action potential output in CA1-PC.

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posted on 2014-03-19, 03:17 authored by Francesco Tamagnini, Sarah Scullion, Jonathan T. Brown, Andrew D. Randall

A) Examples of the action potential firing produced by application of 500 ms depolarizing stimuli of 100 (left), 200 (middle) and 300 pA (right) amplitude applied at a pre-stimulus membrane potential of −80 mV. Data are show for both a control aCSF only CA1-PC (top) and a DMSO pre-treated CA1-PC (bottom). B) A plot of the percentage of recordings in which 1 or more action potential was elicited by the various amplitudes of current stimulus indicated on the ordinate. C) A plot of mean number of spikes versus amplitude of current stimulus for control and DMSO pre-treated CA1-PC. D) A plot of instantaneous action potential frequency versus spike interval for 500 ms current stimuli of 200 pA (left) and 300 pA (right) amplitude.

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