Crystal structure of the ectodomain of ZNRF3.

<div><p>A. Cα trace of ZNRF3 ectodomain coloured from N- to C-terminus (blue through red) and structural elements indicated. The arrow indicates the connection to the single trans-membrane pass.</p> <p>B. Overlay of the Cα trace of ZNRF3 (green) with RNF43 (purple) and RNF128 (orange).</p> <p>C. Two perpendicular views of the dimeric arrangement of ZNRF3 observed in the crystal, with residues at the interface indicated.</p></div>