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Crystal structure of the ectodomain of ZNRF3.

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posted on 2013-12-12, 03:58 authored by Weng Chuan Peng, Wim de Lau, Pramod K. Madoori, Federico Forneris, Joke C. M. Granneman, Hans Clevers, Piet Gros

A. Cα trace of ZNRF3 ectodomain coloured from N- to C-terminus (blue through red) and structural elements indicated. The arrow indicates the connection to the single trans-membrane pass.

B. Overlay of the Cα trace of ZNRF3 (green) with RNF43 (purple) and RNF128 (orange).

C. Two perpendicular views of the dimeric arrangement of ZNRF3 observed in the crystal, with residues at the interface indicated.

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