Coronary artery atherosclerosis in 11-month-old <i>LDLR−/−, LDLR +/−,</i> and <i>LDLR +/+</i> pigs fed a high fat, high cholesterol diet.

<p>Representative H&E stained sections from each group are shown: <i>LDLR−/−</i> (A,B), <i>LDLR +/−</i> (C,D), and <i>LDLR +/+</i> (E,F). Complex lesions were seen in the <i>LDLR−/−</i> pigs (A,B) that exhibited hemorrhage, possible areas of calcification, fibrous caps and foam cells.</p>