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Conformational change induced inhibition of adhesion by nanobodies NbFedF6 and NbFedF7.

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posted on 2014-12-11, 03:04 authored by Kristof Moonens, Maia De Kerpel, Annelies Coddens, Eric Cox, Els Pardon, Han Remaut, Henri De Greve

Superimposition of the FedF-blood group A type 1 hexasaccharide (A6-1) co-complex structure (colored yellow) with the co-complex structures of FedF-NbFedF6 (A) and FedF-NbFedF7 (B) (β-strands, α-helices and loops are colored respectively cyan, red and grey). Both NbFedF6 and NbFedF7 induce a conformational change in the D″-E loop that is protruding from the FedF surface thereby reorienting the loop outwards from the A6-1 binding site. A6-1 is depicted in stick model with carbon, oxygen and nitrogen atoms colored respectively purple, red and blue.

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