Concentrations of biomarkers<sup>*</sup> and univariate and multivariable associations of single biomarkers with eGFR decline.

<p>*Concentrations of nephrin (NPHS1), neuropilin-1 (NRP1), interleukin-1 alpha (IL1A), interleukin-1 beta (IL1B), and epidermal growth factor (EGF) were missing in 10% of observations or undetectable in >25% of observations, and these biomarkers were therefore not used in analysis.</p><p><sup>†</sup>Adjusted for established risk markers: baseline UACR, current vs. never smoker, sex, systolic blood pressure, use of oral diabetic medication, diastolic blood pressure, and baseline eGFR.</p><p>Concentrations of biomarkers<sup><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0120995#t001fn001" target="_blank">*</a></sup> and univariate and multivariable associations of single biomarkers with eGFR decline.</p>