Computational model of homeostatic synaptic plasticity and microdomains.

<p><b>A</b> Schematic presentation of homeostatic synaptic plasticity rule used in the baseline version of the model. Upregulation of synaptic conductances to a neuron was determined by averaging firing rates over the set of synaptic inputs to the neuron under consideration. Downregulation of synaptic conductances to a neuron was determined by the firing rate of this neuron. <b>B</b> Schematic presentation of input segregation into microdomains, where upregulation of synaptic conductances belonging to the same microdomain was determined by averaging over firing rates of neurons that projected these synapses. Downregulating mechanism of synaptic conductance was the same for all synapses (as it was determined by the firing rate of their common postsynaptic neuron).</p>