Figure_1.tif (799.35 kB)
Comparison of the putative topological organization of bacterial and mitochondrial TSPO.
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posted on 2013-02-21, 05:28 authored by Annelise Chapalain, Sylvie Chevalier, Nicole Orange, Laurence Murillo, Vassilios Papadopoulos, Marc G. J. Feuilloley(a) Pseudomonas fluorescens MF37 bactTSPO. (b) BactTSPO from Rhodobacter sphaeroides 2.4.1 recalculated from Yeliseev and Kaplan [12]. (c) Mitochondrial TSPO [13]. P. fluorescens MF37 bactTSPO has a typical five transmembrane helix structure, a larger L1 intra-cytoplasmic loop, and an extended cytoplasmic C-terminal end. In contrast, the extracellular N-terminal end is absent, and a peptidoglycane binding domain signature is present between the L2 loop and H3 transmembrane domain.