Comparison of the Nrf1 expression under hypoxia and proteasomal inhibition.

<p>WFF2002 (<b>A</b>) and COS7 (<b>B</b>) cells were treated with normoxia (21% O<sub>2</sub>), hypoxia (1% O<sub>2</sub>), 10 µM MG-132 or hypoxia and MG-132 combination for six hours and subjected to Western blotting. The band density was normalized with respect to β-tubulin (β-tub) or ponceau S red staining (p. stain) and is presented as means ± SEM of at least three independent experiments for WFF2002 (<b>C</b>) and COS7 (<b>D</b>) cells. Asterisks (*) indicate significant difference (p<0.05) compared to control.</p>