Comparison of 24-h Oscillations between Wild-Type and <i>tim<sup>01</sup></i> Genotypes

<div><p>(A) Direct comparison between value-ordered wild-type and <i>tim<sup>01</sup></i> 24-h Fourier scores. The upward trend represents a clock-dependent enrichment in high-quality circadian oscillations. The same format is used here as for <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020039#pgen-0020039-g002" target="_blank">Figure 2</a>A except that the <i>tim<sup>01</sup></i> Fourier scores take the place of the permutation background model. To compare equal numbers of days in both genotypes, four days of data (2× LD/DD) are used on each axis.</p><p>(B and C) QQ plots comparing the data in panel (A) to a permutation null model (method as in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020039#pgen-0020039-g002" target="_blank">Figure 2</a>A). (B) Comparison of wild-type data to the permutation null model shows that the enrichment in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.0020039#pgen-0020039-g002" target="_blank">Fig. 2</a>A persists (although somewhat damped) with half the amount of data (2xLD/DD). (C) Comparison of <i>tim<sup>01</sup></i> data (2× LD/DD) to the permutation null model shows that 24-h oscillations, if present, are not obviously enriched in the absence of a working circadian clock.</p></div>