Clonogenic ability in vitro after lexatumumab (1 µg/ml) and DTIC (50 µg/ml) treatment of the cell lines.

(A) FEMX-1 and (B) HHMS. The cells were seeded in six well plates and the next day exposed to the indicated treatment. Two weeks later the colonies were fixed, stained with 0.04% crystal violet and counted. Results are expressed relative to untreated control cells and are presented as mean ± standard error of the mean (SEM) of three parallel experiments. Significant difference in clonogenicity after combination treatments relative to DTIC or lexatumumab mono-treatment is indicated by (*).