Chromosomal aberrations 72 h after release from APH treatment.

A: Frequencies of non-clonal chromosomal aberrations. B: Examples of pericentromeric chromosomal aberrations. Centromeric regions were identified by the centromeric constrictions, intenseDAPI staining and pan-centromere FISH (green). First panel: An example of pericentromeric chromosomal deletion. Second panel: An example of pericentromeric chromosomal breaks with both arms present. Third panel: An example of pericentromeric chromosomal translocation. Note that the joined region was at centromeric constriction region with centromere FISH signals. Lowest panel: An example of dicentrics with joined regions involving centromeric ends (Xp and 21p).