Characterization during adult life of the wild type and W441C mutant <i>d-</i>mtDNA helicase.

<p>(A) Longevity curve of lines overexpressing the wild type and W441C mutants using a constitutive and ubiquitous driver (<i>da-GAL4</i>). 100 adult males (0–2 days old) were collected in an empty tube with standard medium and the number of surviving flies was counted every 2 days. Kaplan-Meier survival curve was performed (p = 0.045, n = 3 biological experiments). (B) Quantitation of mtDNA copy number by qRT-PCR at 5, 25 and 50 days of life in both lines.</p>