Characteristics of the patients.

F: female, M: male, pos: positive cases, neg: negative cases; M0 to M7: according to the French-American-British (FAB) diagnosis; 8UC (unclassified AML); nucleophosmin mutations (NPM1), fms-like tyrosine kinase-3 internal tandem duplications and tyrosine kinase domain mutations (FLT3ITD/TKD), mixed-lineage leukemia gene partial tandem duplications and rearrangements (MLL PTD/R); K: karyotype; CK complex karyotype (more than 3 abnormalities), NC-AML: Normal Cytogenetic Karyotype acute myeloid leukemia. To establish normal cytogenetic at least 20 metaphase cells from diagnostic bone marrow had to be evaluated and the karyotype had to be found normal in each mitosis. N: number of cases; +: positive cases; DNMT3Am: stands for mutated DNMT3A; DNMT3BNC: stands for non-catalytic DNMT3B.