Cardiac IL-6 is elevated but does not mediate uPA-induced cardiac fibrosis.

<p><b>A.</b> IL-6 concentrations in explant culture media from hearts of SR-uPA<sup>+/0</sup> and NTG mice. N  = 5 mice per genotype. <b>B.</b> Collagen content of hearts from SR-uPA<sup>+/0</sup> and NTG littermates at 15 weeks of age. Solid circles represent mice heterozygous for IL-6; open circles are mice homozygous (+/+ or −/−) for IL-6. Bars are medians. N  = 3–5 mice per heterozygous or homozygous genotype. <b>C.</b> Macrophage accumulation in hearts of SR-uPA<sup>+/0</sup> and NTG littermates at 7 weeks of age. Solid circles represent mice heterozygous for IL-6; open circles are mice homozygous (+/+ or −/−) for IL-6. Bars are medians. N  = 3–5 mice per heterozygous or homozygous genotype. Representative heart sections stained with picrosirius red of <b>D.</b> NTG mice, <b>E.</b> SR-uPA<sup>+/0 </sup><i>il6</i><sup>+/+</sup> and <b>F.</b> SR-uPA<sup>+/0 </sup><i>il6</i><sup>−/−</sup> mice. Bars represent 100 µm.</p>