Capsaicin sensitizes heat-evoked foot withdrawal to heat in mice, but not naked mole-rats.

Latencies were measured every 10 minutes in mice (A, n = 6) and naked mole-rats (B, n = 6). Saline (i.t., gray traces) or capsaicin (1 mM topical, red traces) were given after the first three time points (black arrows). Whereas saline had no effect upon withdrawal latency in either species, capsaicin induced faster foot withdrawal in mice (A), but had no effect upon naked mole-rats (B).