CRISPR profiles obtained for the 18 strains and two genomes of S. enterica serotype Typhi.

The spacer sequences and direct repeat (DR) sequences are indicated. The set of strains and genomes has been reported elsewhere [15]. “n” is the number of strains harboring each profile. Haplotypes [19] are indicated, to illustrate the genetic diversity of the strains studied. ND, not determined. The primers used for serotype Typhi-specific amplification (TY-F and TY-R) and those for amplification of the entire CRISPR2 sequence (B1 and B2) [15] are indicated in different colors.