COX-2 inhibitor treatment maintains mRNA expression of markers of differentiated smooth muscle.

2013-02-19T19:45:44Z (GMT) by Sarbani Ghoshal Charles D. Loftin
<p>Real-time PCR quantitation of (A) α-actin or (B) hyaluronic acid synthase-2 mRNA expression in the abdominal aorta. Mice were provided control or celecoxib containing diet beginning 1 week after initiating a 6-week AngII infusion. (C) Quantitation of α-actin mRNA expression in the abdominal aorta of mice provided control or celecoxib containing diet beginning 3 weeks after initiating an 8-week AngII infusion. Expression levels of the gene of interest were normalized to HPRT mRNA levels. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0044369#s3" target="_blank">Results</a> indicate mean ± SEM and the number of mice in each group is provided within the graphs. <i>P</i> values were determined using an unpaired two-tailed <i>t</i>-test. * indicates <i>P</i><0.05.</p>