CIPN-myeloma patients demonstrated a0 hyper-activation of precuneus during heat-pain stimulation, compared with healthy volunteers.

<p>Functional imaging data are shown overlaid on both axial (z = 27 mm) and sagittal (x = −18 mm) slices through a canonical single-subject T1-weighted image. For display purposes, the statistical threshold is p<0.001, uncorrected, at the voxel-level. <b>b) Contrast estimates and 90% CI at co-ordinate −18, −61, 27 for both healthy volunteer and CIPN-myeloma patient groups.</b></p>